Polycystic ovary syndrome (PCOS) is caused by a hormonal imbalance. PCOS affects 1 in 10 women of childbearing age and can lead to related health problems such as diabetes and infertility. Although the lack of causes is relatively unknown, there is no cure for PCOS. However, there are natural ways to relieve symptoms. Inositol, referred to as vitamin B8, is one of the ways to help relieve PCOS, and research has shown promising results.

Polycystic ovary syndrome (PCOS) is a hormonal imbalance disorder. Women with PCOS may have irregular menstrual cycles and increased levels of the male hormone androgen. Although the exact cause is unknown, you can manage PCOS to alleviate the symptoms of PCOS and reduce the risk of diabetes with specific supplements for PCOS.

Researchers claim that excess insulin may be a potential cause of PCOS. Insulin is a hormone produced in the pancreas that allows your body to control and use sugar for energy. If you become insulin resistant, your blood sugar levels will rise and your body will make more insulin in response. Excess insulin can increase androgen production, which can lead to ovulation difficulties. Evidence also shows that PCOS may be hereditary.

Inositol, also known as vitamin B8, is a naturally occurring sugar and is also found in a variety of foods such as fruits, grains, beans and legumes. Inositol is a type of sugar alcohol and is considered a pseudovitamin because it is an unnecessary nutrient.

Vitamins are considered essential nutrients because the body cannot synthesize them in sufficient quantities to meet the physical needs and therefore must be obtained through food or supplements.

Inositol may improve insulin resistance

The ovaries are highly sensitive to the effects of insulin and are immune to insulin resistance. Excessive insulin can alter the luteinizing hormone that increases ovarian androgen production.

Inositol is commonly referred to as Vitamin B8, a pseudo-vitamin and a type of sugar made by the body. Foods such as fruits and beans also help maintain the balance of inositol hormones and are a secondary messenger for insulin. Defects in this pathway can lead to impaired insulin signals and insulin resistance. This is the main reason for recommending the use of inositol in the management of insulin resistance syndromes such as polycystic ovary syndrome (PCOS). [R].

There are nine forms of inositol, but studies have shown that the two that have the greatest effect on PCOS are myo-inositol (MI) and de-chiro-inositol (DCI).

It is suggested that Inositol MI and DCI reduce insulin resistance, improve ovarian function, and reduce androgen levels in women with PCOS. [R].

In the ovary, MI and DCI have specific responsibilities. MI supports the FSH signal, where DCI is responsible for insulin-mediated testosterone synthesis. In the normal ovary, these activities maintain balance, which helps maintain normal hormone levels and facilitates ovarian function. In polycystic ovaries, systemic insulin resistance (hyperinsulinmia) strengthens epimerase activity, thus creating a higher DCI-to-MI ratio. It stimulates hyperandrogenism and reduces the effectiveness of MI-mediated FSH signaling.

Studies have shown that inositol can lower testosterone levels and help lower androgen levels. The duration of treatment, however, is important to help relieve the symptoms which takes a minimum of 6 months to see an overall reduction. [R].

Myo-inositol has been shown to help women with PCOS recover ovulation. MI is the second messenger of follicle-stimulating hormone (FSH) and DCI is the aromatase inhibitor. Combined administration of both Mayo-Inositol and DCI in a 40: 1 ratio, can increase fertility for pregnancy in women with PCOS. [R].

A meta-analysis published in the journal Molecules Inositol investigators in PCOS identified 35 randomized controlled trials. Most studies have shown that MI treatment improves ovarian function and fertility, reduces the severity of hyperandrogenism, including acne and hirsutism, positively affects metabolic aspects, and improves reproductive axis function and ovulation. Thus, treatment with MI has become a fancy method to reduce PCOS symptoms, improve spontaneous ovulation, or induce ovulation. [R].

Studies show that a combination of mayo-inositol and de-chiro-inositol may help relieve the symptoms of PCOS and improve the menstrual cycle, ovulation, hormonal balance, insulin control, and metabolic changes. Inositol treatment for PCOS is much cheaper than other fertility treatments. Consult your healthcare provider to find out if Inositol or Combination Therapy is the right protocol for you before using Inositol or Combination Therapy.

References

Kalra, Bharati etc. “Inositol and polycystic ovary syndrome.” Indian Journal of Endocrinology and Metabolism Volume 20.5 (2016): 720-724. doi: 10.4103 / 2230-8210.189231

Anfar, Vittorio et al. “Myo-inositol effects in women with PCOS: a meta-analysis of randomized controlled trials.” Endocrine connectivity Volume 6.8 (2017): 647-658. doi: 10.1530 / EC-17-0243

Efficacy of mayo-inositol in the treatment of skin diseases in young women with polycystic ovary syndrome. Gynecological endocrinology 2009. 25 508-513. (10.1080 / 09513590903015544)

Fachinetti F, Anfar V, Dewali D, Kamenov ZA, Diamanti-Kandarkis E, Lagana AS, Nessler Jay, Solez CO; Inositol group in the field of PCOS and reproduction. Inositol in Polycystic Ovary Syndrome: An Overview of Progress. Trends endocrinol metab. 2020 June; 31 (6): 435-447. doi: 10.1016 / j.tem.2020.02.002. Epub 2020 9 March. PMID: 32396844.

Kamenov Z, Getosa at PCOS, Inositles. Molecules. November 27, 2020; 25 (23): 5566. doi: 10.3390 / molecules25235566. PMID: 33260918; PMCID: PMC7729761.

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